The NIH-AARP diet and health study found that diabetes is associated with the reduction of the risk of cancer of the prostate in men, but with an increased risk of other types of cancer in men and women. The data presented at the annual meeting of 102 AACR 2011 in Orlando, Florida, 2-6 April, showed an association between diabetes and higher rates of cancer mortality.
Previous epidemiological studies have demonstrated an association between diabetes and increased risk of cancer, including cancer of the liver and pancreas, according to the prevention of cancers companions, Gabriel Lai, Ph.d., National Cancer Institute.
Their results also provide evidence of abnormal insulin and glucose signaling can contribute to the development and the initiation of cancer. There are countless benefits to avoid diabetes by exercise, diet and maintain a healthy weight. Their study confirms additional advantages in reduction of morbidity and mortality of certain types of cancer."
Lai and his colleagues conducted a prospective study using data from more than 500 000 non-Hispanic whites mainly of men and women aged 50 to 71 years. From 1995 to 1996, participants completed the questionnaire on diet and lifestyle, or were not diabetes. Researchers followed patients for 11 years.
Results showed that diabetes was associated with a risk of 8% increased cancer among women and 4 per cent decreased the risk for men. In previous research, a decrease in the risk of prostate cancer associated with diabetes, the researchers believe that it could be due to low testosterone associated with diabetes. After their evaluation of cancer of the prostate, Lai and his colleagues concluded that diabetes was associated with increased risk by 9 per cent for cancer in men.
With regard to mortality, diabetes was associated with an increased risk of 11% in women and the risk of 17 per cent higher among men.
"These risks appeared to be independent of other risk factors, such as smoking and obesity", said Lai.
After evaluating the cancer site, the researchers found diabetes was associated with a significant increase in the risk of colon cancer, rectal and liver cancer between men and women. Men, were associated with an increased risk of diabetes, the pancreas and bladder cancer. Among women, risk has been associated with increased stomach, endometrial cancer and anal cancers. We have not found no association between diabetes and lung, skin or other types of cancer.
"Follow-up studies to identify the biological mechanisms involved must be taken to take advantage of the confirmed results," said Lai.
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