Carbohydrate for brake is more effective than the calories of Cup for people who want to rapidly reduce the amount of fat in their livers, researchers at UT Southwestern Medical Center report .
"What this study tells us is if the doctor has said that it is necessary to reduce the amount of fat in the liver may be done in a month," said Dr. Jeffrey Browning, Assistant Professor of medicine, internal in the UT Southwestern and senior author of the study.
The results, available online and in a next issue of the American Journal of Clinical Nutrition, may have implications for the treatment of many diseases, including diabetes, insulin resistance and part fat liver disease or NAFLD. The disease, characterized by high levels of triglycerides in the liver, affects up to one third of American adults. It can lead to inflammation of the liver, cirrhosis and liver cancer.
The study, researchers have attributed to 18 participants with NAFLD to eat a low-carbohydrate diet or a diet low in calories for 14 days.
Participants assigned to the diet low carbohydrate limited their carbohydrate intake less than 20 grams per day – the equivalent of a small banana or a cup half of noodles - during the first seven days. For the last seven days, changed dishes frozen by the needs of the clinic of UT Southwestern and kitchen (CTRC) applied research Centre that correspond to their individual preferences, the hydrates of carbon and energy consumption.
Those assigned to low calorie diet have continued their regular diet and kept a journal of food during the four days before the study. The CTRC kitchen will use these individual records to prepare all meals during the 14 days study. Researchers had limited the total number of calories to about 1,200 participants 1 500 per day for men and women daily.
After two weeks, the researchers used advanced imaging techniques to analyze the quantity of foie gras to each individual. They found that participants of the study on the diet low carbohydrate lost more than foie gras.
Although the study did not determine what diet was more effective to lose the weight, low in calories and low in carbohydrates on average lose 10 pounds.
Dr. Browning cautioned that the findings do not explain why the low carbohydrate diet participants saw a further reduction of fatty liver, and which can be extrapolated beyond the period of two weeks of study.
"It is not a long-term study, and I do not think that the low carbohydrate diet is fundamentally better than, low fat," said. "Our approach is likely to only benefit in the short term because at one time the benefits of weight loss only break the benefits of dietary macronutrient manipulation as the calories and carbohydrate."
"The loss of weight, regardless of the mechanism, is currently the most effective way to reduce liver fat."
Other UT Southwestern researchers involved in the study were Dr. Shawn Burgess, lead author and Professor of Pharmacology; in the Advanced Imaging Research Center (AIRC) Dr. Jonathan Baker, Professor of pathology. Dr. Thomas Rogers, former Professor of pathology. Jeannie Davis, Coordinator of clinical research in the AIRC. and Dr. Santhosh Satapati, researcher post-doc at the AIRC.
The national institutes of health supported the study.
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