Nobody can explain this strange phenomenon. Most type 2 diabetics, undergoing metabolic surgery recover from diabetes a few days only after the intervention, well before there was weight loss. Diabetes Centre, Lund University researchers are now considering whether what is happening through the study of patients and pigs after and before metabolic surgery.
"Given that the recovery of diabetes occurs so early, a process other than weight loss must be behind it. "If we can identify and emulate this process may result in completely new forms of treatment of type 2 diabetes" said Nils Wierup, one of the researchers behind the study.
There is a strong correlation between being overweight or obesity and type 2 diabetes, and many people with diabetes can be on their way to recovery if they lose weight, but it is not the objective of the study. Instead, the objective is a side-effect - standardization surprisingly quickly from homeostasis of glucose, which is at 85 percent of diabetics after metabolic surgery.
Gastric bypass mean redirecting the content of food directly in the small intestine, stomach bypass. This means that the parties to become the smallest weight and long-term loss becomes important.
"Does not mean that all people with diabetes type 2 must undergo surgery, but perhaps we can learn and get the same anti-diabetic effect without surgical intervention," said Nils Wierup.
Patients will be invited to participate in the study is of type 2 diabetics will have surgery gastric bypass. They pass through a variety of tests before and periodically after surgery.
The research team will also use pigs, healthy and diabetes experiments that can not be performed on patients will be performed on the pigs.
"Pigs are suitable because they resemble humans in many ways, including anatomic and gastrointestinal hormones,", said Nils Wierup, adding that it is possible that a less extensive gastric bypass may have the same dramatic effects.
"In this case the region we have to look for will be less and will make it easier to find a mechanism that we are looking for."
In the list of suspected factors are changes in the effects of gastrointestinal hormones. It is known that the secretion of the hormone in gastrointestinal tract plays an important role in the homeostasis of glucose. Gastric bypass surgery changed conditions. Metabolic surgery can also dramatically change the gastro-intestinal bacterial flora changes in pH, and this means that the other species of bacteria can be placed.
"But it might also be a completely different mechanism. We have to look at a variety of factors,"said Hindrik Mulder, one of the team members.
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