Two small trials published online in the British Medical Journal suggests that closed-loop insulin (also known as the artificial pancreas) delivery may improve glycemic control during the night and reduce the risk of nocturnal hypoglycaemia (a sudden fall in blood glucose levels of) (blood night) in adult patients with diabetes Type 1.
The number of people with diabetes type 1 is growing at a rate of 3% by the year, especially among white people of European North. Permanent insulin therapy is necessary to control the blood glucose levels, but the risk of hypoglycemia is always a challenge, especially during the night.
Recent advances have led to the development of a system of delivery of the closed-loop insulin which automatically calculates the dose of insulin in accordance with the levels of glucose, detected by a sensor. Previous studies have shown that this system is effective in children and adolescents, but their effectiveness in adults is unknown.
a team of researchers led by Roman Hovorka, Cambridge University, conducted two studies to compare the safety and effectiveness of the delivery of insulin loop closed during the night with a treatment by classic in adult patients with diabetes type 1 insulin pump.
The Group was formed by 24 adults (10 men and 14 women) 18-65, wearing the pump therapy insulin for at least three months.
In the first study, 12 participants were monitored two times during the night after a meal of average size (60 g carbohydrates) to 19 h: were assigned at random to use any delivery of classic loop closed insulin or insulin etpuis in a pump at night one to three weeks later they used another method of delivery. In the second study, 12 other participants have been controlled twice during the night (with one or the other of the two methods of insulin delivery) after consuming a large meal (100 g carbohydrates) at 20: 30 accompanied by alcohol.
Time with the levels of blood glucose in the destination range increased by 28% over the closed-loop insulin at night. Closed-loop delivery also fell overnight glucose variability and significantly reduces the time spent hiperglucémicos.
These findings provide further evidence to closed-loop delivery of night can work in safe, efficient and systematic way across different age groups, insulin sensitivity and the conditions of life, conclude the authors.
They add that the system of closed circuit "in the future to allow more flexible ways of life with glucose control for people with diabetes type 1."
In an accompanying editorial, Professor Boris Gorge, from the University of Virginia said that, with the promise closed of a sample of control loop, within a framework of research development and miniaturization of the system is necessary in practice to improve the health and lives of people with diabetes type 1.
Social Plugin