Directed by the school of Medicine of the University of Warwick, Warwick has found that metformin, a drug used for the treatment of diabetes and treatment in women with Polycystic change syndrome (PCOS) can potentially provide protection against endometrial cancer.
Endometrial cancer is the most frequent female genital cancer and fourth cancer among women in the United Kingdom and the United States. Up to one third of the central offices, women also have hyperplasia endometrial inclines to turn these women for endometrial cancer. SOP to 5-10% of women age of childbearing, which metformin improves insulin resistance and hyperinsulinemia in these women, but also improves long-term metformin uses the regularity of the menstrual cycle and ovulation.
Recent research found that metformin has anti-cancer properties, for example, in breast cancer. For example, given that resistant to insulin, obesity, diabetes and the SOP States risk of developing cancer of the endometrium, researchers from Warwick studied the effects of metformin treatment in endometrial cancer cells. Researchers use the control serum and the themes of the offices carried out fundamental scientific experiments in endometrial cancer cells and Central (before and after treatment of metformin). The experiments showed a decrease of invasiveness of cancer of the endometrium cells in Sera from treated metformin PCOS women.
Researchers have discovered that when samples of serum from women from central offices who have completed 6 months of metformin, the speed of propagation of endometrial cancer cells is about 25% less than in the serum of women of the centrauxqu offices ' they had not begun to this treatment.
Principal investigator, Dr. Harpal Randeva and Dr. Bee K Tan, Warwick medical school, said: "we are very pleased of our conclusions, which revealed the significant impact of the use of metformin therapy in cells with human endometrial cancer.". However, it is prudent to advance research to explore if metformin is actually clinically beneficial therapy for endometrial cancer; "It shall be resolved by a randomized controlled trial."
Social Plugin